IIT/Engineering

IIT Roorkee prof study finds Fbln7-C can delay programming process

New Delhi :
A study by Indian Institution of Technology, Roorkee (IIT Roorkee) professor Pranita Sarangi has found that Fbln7-C can delay the reprogramming process of macrophages present in the tumor tissues, also known as tumor associated macrophages (TAMs), while directly inhibiting the proliferation of cancer cells. This study will be useful for oncological & immunological cancer research & designing therapeutics.

This study used various in vitro systems –

IIT Roorkee As the cancer progress, the macrophages that are initially recruited into the cancer site to assist in the removal of the cancer cells get reprogrammed to produce certain protein substances that help the cancers to grow and spread to different parts of the body. This study used various in vitro systems and an animal breast tumor model to highlight that Fbln7-C could help the macrophages to resist the reprogramming process and delay the conversion of anti-tumorigenic to pro-tumorigenic TAMs, while directly inhibiting the proliferation of cancer cells.

Animals injected with Lipopolysaccharide (LPS) –

Another study of her stated, Fbln7-C can regulate the inflammatory functions of human neutrophils, (cell type that works as the first line of defense of our immune system) and administration of Fbln7-C could improve survival in animals injected with Lipopolysaccharide (LPS), a cell wall content of gram-negative bacteria.

Commentary published in the same journal by researchers –

The study is published in The FEBS Journal, an official publication of the Federation of European Biochemical Societies. This work was also highlighted in a commentary published in the same journal by researchers from IIT Bombay. Prof Pranita Sarangi had received funds from the DBT-Govt of India (Innovative Young Biotechnologist Award-2017) for this work.

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Former student of IIT Madras creates a fabric that can kill bacteria and air-borne viruses

New Delhi :
Deepthi Nathala, a former student of Indian Institute of Technology, Madras (IIT Madras) has created a fabric that can kill bacteria, air-borne viruses & provide protection against pollution. The fabric has also been tested against the COVID-19 virus & Deepthi is scaling up the production of washable, reusable face masks & headgear that are environment-friendly.

Hosted by TiE Hyderabad recently –

The mask made up of this fabric has protective covering that not only protects you from dust and grime, but claims to block 99 per cent UV rays, 95 per cent air pollution, and inhibits/kills 99 per cent bacteria and viruses! At the TiE Women Regional Finals, hosted by TiE Hyderabad recently, Hyderabad-based Dibbu Solutions, founded by Deepthi Nathala, was adjudged the first runner-up for their product ‘Hecoll’, a washable and reusable face mask and headgear that protects us from airborne viruses.

fabric is antibacterial, antifungal, anti-dust, anti-pollution –

“The fabric is proven and tested against H1N1, Covid-19, Ecoli, and Salmonella and is safe against dust, S02, NO2, pollen and ultraviolet A and B sun rays,” says Deepthi, a 2007 IIT-Madras alumnus. Some of their innovative products include Hecoll anti-virus fabric and products. According to Deepthi, the one-year-old Hyderabad-based startup manufactures textile using disinfectants. “The fabric is antibacterial, antifungal, anti-dust, anti-pollution and is technically engineered self-disinfectant cotton,” shares Deepthi. She moved back to India last year after working in California, USA, and Dubai, UAE.

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